MDL 28170

Tocris Bioscience, part of Bio-Techne | Catalog # 1146

Potent, selective calpain and cathepsin B inhibitor
Discontinued Product
1146 has been discontinued. View all Calcium-Sensitive Protease Modulator Inhibitors products.

Key Product Details

Description

Potent, selective calpain and cathepsin B inhibitor

View all Calcium-Sensitive Protease Modulator Inhibitors »

Product Description

Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Product Specifications

Molecular Weight

382.45

Formula

C22H26N2O4

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal

CAS Number

88191-84-8

PubChem ID

11199915

InChI Key

NGBKFLTYGSREKK-ANYOKISRSA-N

SMILES

O=C(N[C@@H]([C@H](C)C)C(NC(CC2=CC=CC=C2)C([H])=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.24 100

Preparing Stock Solutions for MDL 28170

The following data is based on the product molecular weight 382.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Product Documents for MDL 28170

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MDL 28170

For research use only

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