MDL 100907

Name: MDL 100907
Brand: Tocris Bioscience
SKU: 4173

Tocris Bioscience, part of Bio-Techne | Catalog # 4173

Citations (38)

COA / SDS

Potent and selective 5-HT2A antagonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective 5-HT2A antagonist

Alternative Names

Volinanserin

View all 5-HT2A Receptor Antagonists »

Product Description

MDL 100907 is a potent and selective 5-HT_2A receptor antagonist (K_i = 0.36 nM, IC₅₀ = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT_2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo.

Product Specifications

Molecular Weight

373.46

Formula

C₂₂H₂₈FNO₃

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

CAS Number

139290-65-6

PubChem ID

5311271

InChI Key

HXTGXYRHXAGCFP-OAQYLSRUSA-N

SMILES

FC(C=C3)=CC=C3CCN(CC2)CCC2[C@@H](O)C1=C(OC)C(OC)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	18.67	50
	DMSO	37.35	100

Preparing Stock Solutions for MDL 100907

The following data is based on the product molecular weight 373.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Sorensen Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J.Pharmacol.Exp.Ther. 1993 PMID: 8102646
Ardayfio The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant dr J.Pharmacol.Exp.Ther. 2008 PMID: 18772320
Kehne Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J.Pharmacol. 1996 PMID: 8627580