MC 1 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8843
Selective EP300 Degrader (PROTAC®)
Key Product Details
Description
Selective EP300 Degrader (PROTAC®)
Product Description
MC 1 is a selective lysine acetyltransferase EP300 DegraderPROTAC®. Displays selectivity for EP300 over CREBBP. Comprises an EP300-binding moiety (CPI-1612) joined by a linker to VH032 as the ligand for von Hippel-Lindau E3 ubiquitin ligase. MC 1 inhibits cell proliferation in a subset of cancer cell lines and can be used to investigate the noncatalytic functions of EP300 and CREBBP.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license
Product Specifications
Molecular Weight
1062.35
Formula
C59H71N11O6S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-(8-(2-(4-(6-((R)-2-(((S)-2-(4-Cyanophenyl)propyl)amino)-2-phenylacetamido)pyridin-3-yl)-1H-pyrazol-1-yl)acetamido)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChI Key
NKGYKZVOVOJLDL-HITCUEKTSA-N
SMILES
O=C(CCCCCCCNC(CN1N=CC(C2=CC=C(NC([C@H](NC[C@@H](C)C3=CC=C(C#N)C=C3)C4=CC=CC=C4)=O)N=C2)=C1)=O)N[C@H](C(N5[C@H](C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)C[C@@H](O)C5)=O)C(C)(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.62 | 10 with gentle warming |
Preparing Stock Solutions
for MC 1
The following data is based on the product molecular weight 1062.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.41 mL | 47.07 mL | 94.13 mL |
| 0.5 mM | 1.88 mL | 9.41 mL | 18.83 mL |
| 1 mM | 0.94 mL | 4.71 mL | 9.41 mL |
| 5 mM | 0.19 mL | 0.94 mL | 1.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen Paralogue-selective degradation of the lysine acetyltransferase EP300. JACS Au. 2024 PMID: 39211607
Product Specific Notices for MC 1
For research use only
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