Maraviroc

Name: Maraviroc
Brand: Tocris Bioscience
SKU: 3756
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3756

(1)

Citations (40)

COA / SDS

Selective CCR5 antagonist

Key Product Details

Description:	Selective CCR5 antagonist
Alternative Names:	UK-427857
Chemical Name:	4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	513.67

View Full Technical Details for Maraviroc

Technical Data
Citations / Reviews (1)

Biological Activity for Maraviroc

Maraviroc is a selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC₅₀ = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1α) binding to CCR5. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries for Maraviroc

Maraviroc is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Maraviroc

M. Wt	513.67
Formula	C₂₉H₄₁F₂N₅O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	376348-65-1
PubChem ID	483407
InChi Key	GSNHKUDZZFZSJB-ILVMPNSOSA-N
Smiles	O=C(C4CCC(F)(F)CC4)N[C@@H](CCN2C3CCC2CC(N5C(C)=NN=C5C(C)C)C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Maraviroc

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.53	75
	ethanol	51.37	100

Preparing Stock Solutions for Maraviroc

The following data is based on the product molecular weight 513.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.73 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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Reconstitution Calculator

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References for Maraviroc

References are publications that support the biological activity of the product.

Piotrowska Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies. Neuropharmacology 2016 PMID: 27117708
Garcia-Perez New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection. J.Biol.Chem. 2011 PMID: 21118814
Kuritzkes Fresh from the pipeline - mara. Nat.Rev.Drug Discov.
Dorr Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob.Agents Chemother. 2005 PMID: 16251317