M62812
Tocris Bioscience, part of Bio-Techne | Catalog # 5705
TLR-4 inhibitor
Discontinued Product
5705 has been discontinued.
View all Toll-like Receptor Inhibitors products.
Product Description
M62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.Product Specifications
Molecular Weight
330.23
Formula
C13H11N3OS.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
CAS Number
613263-00-6
PubChem ID
44224214
InChI Key
SMTKPLISDFNJDJ-UHFFFAOYSA-N
SMILES
NC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.02 | 100 | |
| DMSO | 16.51 | 50 |
Preparing Stock Solutions
for M62812
The following data is based on the product molecular weight 330.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.14 mL | 30.28 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.06 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nakamura Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 2007 PMID: 17588563
Product Specific Notices for M62812
For research use only
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