M 344

Name: M 344
Brand: Tocris Bioscience
SKU: 2771

Tocris Bioscience, part of Bio-Techne | Catalog # 2771

COA / SDS

Histone deacetylase inhibitor

Discontinued Product

2771 has been discontinued. View all Class I Histone Deacetylases Inhibitors products.

Key Product Details

Description:	Histone deacetylase inhibitor
Chemical Name:	4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	307.39

View Full Technical Details for M 344

Technical Data
Citations

Biological Activity for M 344

M 344 is a histone deacetylase inhibitor (IC₅₀ = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.

Technical Data for M 344

M. Wt	307.39
Formula	C₁₆H₂₅N₃O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	251456-60-7
PubChem ID	3994
InChi Key	MXWDSZWTBOCWBK-UHFFFAOYSA-N
Smiles	O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for M 344

References are publications that support the biological activity of the product.

Takai M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol.Oncol. 2006 PMID: 16263156
Riessland The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum.Genet. 2006 PMID: 16724231
Jung Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J.Med.Chem. 1999 PMID: 10579829

M 344

Tocris Bioscience, part of Bio-Techne | Catalog # 2771

Key Product Details

Biological Activity for M 344

Technical Data for M 344

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for M 344

Product Documents for M 344

COA

Certificate of Analysis

SDS

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