Lyn peptide inhibitor

Name: Lyn peptide inhibitor
Brand: Tocris Bioscience
SKU: 2265

Tocris Bioscience, part of Bio-Techne | Catalog # 2265

Citations (5)

COA / SDS

Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable

Discontinued Product

2265 has been discontinued. View all Additional Cytokine Receptor Products products.

Key Product Details

Description:	Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
Molecular Weight:	2370.91

View Full Technical Details for Lyn peptide inhibitor

Technical Data
Citations

Biological Activity for Lyn peptide inhibitor

Lyn peptide inhibitor is a cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

Technical Data for Lyn peptide inhibitor

M. Wt	2370.91
Formula	C₁₁₅H₁₈₄N₃₀O₂₄
Single Letter Sequence	YGYRLRRKWEEKIPNP (Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	222018-18-0
PubChem ID	90001265
InChi Key	MITSVNFZLBORMW-QMGLJYLZSA-N
Smiles	CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Lyn peptide inhibitor

References are publications that support the biological activity of the product.

Adachi A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 1999 PMID: 10395690
Adachi The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 1999 PMID: 9973406

Lyn peptide inhibitor

Tocris Bioscience, part of Bio-Techne | Catalog # 2265

Key Product Details

Biological Activity for Lyn peptide inhibitor

Technical Data for Lyn peptide inhibitor

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Lyn peptide inhibitor

Product Documents for Lyn peptide inhibitor

COA

Certificate of Analysis

SDS

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