LYN 1604 dihydrochloride

Name: LYN 1604 dihydrochloride
Brand: Tocris Bioscience
SKU: 6617

Tocris Bioscience, part of Bio-Techne | Catalog # 6617

COA / SDS

Potent UNC-51-like kinase 1 (ULK1) agonist

Key Product Details

Description:	Potent UNC-51-like kinase 1 (ULK1) agonist
Chemical Name:	2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	657.54

View Full Technical Details for LYN 1604 dihydrochloride

Technical Data
Citations

Biological Activity for LYN 1604 dihydrochloride

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC₅₀ = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC₅₀ = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.

Technical Data for LYN 1604 dihydrochloride

M. Wt	657.54
Formula	C₃₃H₄₃Cl₂N₃O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2310109-38-5
PubChem ID	131954512
InChi Key	GZCBLOPFZPJUOQ-UHFFFAOYSA-N
Smiles	O=C(CN(CC(C)C)CC(C)C)N1CCN(CC(C2=CC=C(C=C2Cl)Cl)OCC3=CC4=C(C=CC=C4)C=C3)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LYN 1604 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	6.58	10

Preparing Stock Solutions for LYN 1604 dihydrochloride

The following data is based on the product molecular weight 657.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.21 mL	76.04 mL	152.08 mL
0.5 mM	3.04 mL	15.21 mL	30.42 mL
1 mM	1.52 mL	7.60 mL	15.21 mL
5 mM	0.30 mL	1.52 mL	3.04 mL

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References for LYN 1604 dihydrochloride

References are publications that support the biological activity of the product.

Zhang UNC-51-like Kinase 1: from an autophagic initiator to multifunctional drug target. J.Med.Chem. 2018 PMID: 29509411
Zhang Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem.Sci. 2017 PMID: 28553505
Zhang ULK1 suppresses osteoclast differentiation and bone resorption via inhibiting Syk-JNK through DOK3. Oxid.Med.Cell Longev. 2021 PMID: 34820053