LYN 1604 dihydrochloride

Product Description

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC₅₀ = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC₅₀ = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.

Solubility

Preparing Stock Solutions for LYN 1604 dihydrochloride

The following data is based on the product molecular weight 657.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.21 mL	76.04 mL	152.08 mL
0.5 mM	3.04 mL	15.21 mL	30.42 mL
1 mM	1.52 mL	7.60 mL	15.21 mL
5 mM	0.30 mL	1.52 mL	3.04 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang UNC-51-like Kinase 1: from an autophagic initiator to multifunctional drug target. J.Med.Chem. 2018 PMID: 29509411
• Zhang Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem.Sci. 2017 PMID: 28553505
• Zhang ULK1 suppresses osteoclast differentiation and bone resorption via inhibiting Syk-JNK through DOK3. Oxid.Med.Cell Longev. 2021 PMID: 34820053