LY 487379 hydrochloride

Name: LY 487379 hydrochloride
Brand: Tocris Bioscience
SKU: 3283

Tocris Bioscience, part of Bio-Techne | Catalog # 3283

Citations (3)

COA / SDS

Selective positive allosteric modulator of mGlu2 receptors

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective positive allosteric modulator of mGlu2 receptors

View all Group II mGluR Modulators »

Product Description

LY 487379 hydrochloride is a positive allosteric modulator selective for mGlu₂ receptors. Potentiates glutamate-stimulated [³⁵S]GTPγS binding (EC₅₀ values are 1.7 and > 10 μM for mGlu₂ and mGlu₃ receptors respectively). Devoid of any activity at mGlu₅ and mGlu₇ receptors. Promotes cognitive flexibility in a rat model.

Product Specifications

Molecular Weight

488.91

Formula

C₂₁H₁₉F₃N₂O₄S.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride

CAS Number

353229-59-1

PubChem ID

56972206

InChI Key

LPWFRDWTOKLHJC-UHFFFAOYSA-N

SMILES

O=S(N(CC3=CC=CN=C3)C1=CC=C(OC2=CC=CC=C2OC)C=C1)(CC(F)(F)F)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.89	100
	Ethanol	24.45	50

Preparing Stock Solutions for LY 487379 hydrochloride

The following data is based on the product molecular weight 488.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.23 mL	20.45 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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Background References

References are publications that support the biological activity of the product.

Nikiforuk Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J.Pharmacol.Exp.Ther. 2010 PMID: 20739457
Schaffhauser Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol.Pharmacol. 2003 PMID: 14500736
Poisik Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology 2005 PMID: 15993439
Johnson Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,-trifluoroethylsulfonyl)pyrid-3-ylmethyl-amine. J.Med.Chem. 2003 PMID: 12852748