LY 341495
Tocris Bioscience, part of Bio-Techne | Catalog # 1209
Highly potent and selective group II mGlu antagonist
Key Product Details
Description
Highly potent and selective group II mGlu antagonist
Product Description
LY 341495 is a highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8 , mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo.Disodium salt (Cat. No. 4062) also available.
Licensing Information
Sold with the permission of Eli Lilly and CompanyProduct Specifications
Molecular Weight
353.37
Formula
C20H19NO5
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
CAS Number
201943-63-7
PubChem ID
9819927
InChI Key
VLZBRVJVCCNPRJ-KPHUOKFYSA-N
SMILES
[H][C@]4([C@@H]([C@](O)=O)C4)[C@](N)(C(O)=O)CC2C3=C(C=CC=C3)OC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.77 | 5 with gentle warming | |
| 1.2eq. NaOH | 35.34 | 100 |
Preparing Stock Solutions
for LY 341495
The following data is based on the product molecular weight 353.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.15 mL | 28.30 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ornstein 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav J.Med.Chem. 1998 PMID: 9464367
- Johnson [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 1999 PMID: 10530814
- Kingston LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 1998 PMID: 9680254
- Fitzjohn The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 1998 PMID: 9886667
Product Specific Notices for LY 341495
For research use only
Loading...
Loading...
Loading...