LY 310762 hydrochloride

Name: LY 310762 hydrochloride
Brand: Tocris Bioscience
SKU: 3078

Catalog # 3078 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective 5-HT1D antagonist

Key Product Details

Description:	Selective 5-HT_1D antagonist
Chemical Name:	1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	430.94

View Full Technical Details for LY 310762 hydrochloride

Technical Data
Citations (1) / Reviews

Biological Activity for LY 310762 hydrochloride

LY 310762 hydrochloride is a 5-HT_1D-preferring receptor antagonist (EC₅₀= 31 nM). Displays no activity on 5-HT transport.

Licensing Information

Sold under license from Eli Lilly and company

Compound Libraries for LY 310762 hydrochloride

LY 310762 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 310762 hydrochloride

M. Wt	430.94
Formula	C₂₄H₂₇FN₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	192927-92-7
PubChem ID	11957576
InChi Key	BOCLFQZPFYNVFD-UHFFFAOYSA-N
Smiles	CC(C1=CC=CC=C1N2CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)(C)C2=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 310762 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.31	10
	DMSO	43.09	100

Preparing Stock Solutions for LY 310762 hydrochloride

The following data is based on the product molecular weight 430.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.60 mL	23.21 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for LY 310762 hydrochloride

References are publications that support the biological activity of the product.

Pullar The role of the 5-HT_1D receptor as a presynaptic autoreceptor in the guinea pig. Eur.J.Pharmacol. 2004 PMID: 15189767

Citations for LY 310762 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for LY 310762 hydrochloride include:

Conley et al. (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Pain. 352:53
PMID: 25332454

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