LY 303511
Tocris Bioscience, part of Bio-Techne | Catalog # 2418
Negative control of LY 294002 (Cat. No. 1130)
Discontinued Product
2418 has been discontinued.
View all PI 3-Kinase Inhibitors products.
Key Product Details
Description
Negative control of LY 294002 (Cat. No. 1130)
Product Description
LY 303511 is a negative control compound for LY 294002 PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.Active Analog also available.
Product Specifications
Molecular Weight
306.36
Formula
C19H18N2O2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
CAS Number
154447-38-8
PubChem ID
3971
InChI Key
NGAGMBNBKCDCDJ-UHFFFAOYSA-N
SMILES
O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCNCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 30.64 | 100 | |
| DMSO | 30.64 | 100 |
Preparing Stock Solutions
for LY 303511
The following data is based on the product molecular weight 306.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.26 mL | 16.32 mL | 32.64 mL |
| 5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Choi LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Letters. 2004 PMID: 14960322
- Kristof LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J.Pharmacol.Exp.Ther. 2005 PMID: 15923340
- El-kholy The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism. FASEB J. 2003 PMID: 12586735
Product Specific Notices for LY 303511
For research use only
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