LY 303511

Name: LY 303511
Brand: Tocris Bioscience
SKU: 2418

Tocris Bioscience, part of Bio-Techne | Catalog # 2418

COA / SDS

Negative control of LY 294002 (Cat. No. 1130)

Discontinued Product

2418 has been discontinued. View all PI 3-Kinase Inhibitors products.

Key Product Details

Description:	Negative control of LY 294002 (Cat. No. 1130)
Chemical Name:	2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
Purity:	≥99% (HPLC)
Molecular Weight:	306.36

View Full Technical Details for LY 303511

Technical Data
Citations

Biological Activity for LY 303511

LY 303511 is a negative control compound for LY 294002 PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K_v) channels (IC₅₀ = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.

Active Analog also available.

Technical Data for LY 303511

M. Wt	306.36
Formula	C₁₉H₁₈N₂O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	154447-38-8
PubChem ID	3971
InChi Key	NGAGMBNBKCDCDJ-UHFFFAOYSA-N
Smiles	O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 303511

References are publications that support the biological activity of the product.

Choi LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Letters. 2004 PMID: 14960322
Kristof LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J.Pharmacol.Exp.Ther. 2005 PMID: 15923340
El-kholy The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K_V currents via a direct mechanism. FASEB J. 2003 PMID: 12586735

LY 303511

Tocris Bioscience, part of Bio-Techne | Catalog # 2418

Key Product Details

Biological Activity for LY 303511

Technical Data for LY 303511

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LY 303511

Product Documents for LY 303511

COA

Certificate of Analysis

SDS

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