LY 266097 hydrochloride

Name: LY 266097 hydrochloride
Brand: Tocris Bioscience
SKU: 4081

Tocris Bioscience, part of Bio-Techne | Catalog # 4081

Citations (4)

COA / SDS

Selective 5-HT2B antagonist

Key Product Details

Description:	Selective 5-HT_2B antagonist
Chemical Name:	1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	407.33

View Full Technical Details for LY 266097 hydrochloride

Technical Data
Citations

Biological Activity for LY 266097 hydrochloride

LY 266097 hydrochloride is a selective 5-HT_2B receptor antagonist (pK_i = 9.3). More than 100-fold selective over 5-HT_2A and 5-HT_2C. Attenuates amphetamine-induced locomotion in the rat.

Compound Libraries for LY 266097 hydrochloride

LY 266097 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 266097 hydrochloride

M. Wt	407.33
Formula	C₂₁H₂₃ClN₂O₂.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	172895-39-5
PubChem ID	9953184
InChi Key	KPXKZZURYAXZQE-UHFFFAOYSA-N
Smiles	CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 266097 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.73	100
	ethanol	40.73	100

Preparing Stock Solutions for LY 266097 hydrochloride

The following data is based on the product molecular weight 407.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.28 mL	24.55 mL
5 mM	0.49 mL	2.46 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for LY 266097 hydrochloride

References are publications that support the biological activity of the product.

Auclair The central serotonin_2B receptor: a new pharmacological target to modulate the mesoaccumbens DArgic pathway activity. J.Neurochem. 2010 PMID: 20534001
Audia Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT_2B) contractile receptor in the rat stomach fundus. J.Med.Chem. 1996 PMID: 8709108