LY 266097 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4081
Selective 5-HT2B antagonist
Product Description
LY 266097 hydrochloride is a selective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.Product Specifications
Molecular Weight
407.33
Formula
C21H23ClN2O2.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
CAS Number
172895-39-5
PubChem ID
9953184
InChI Key
KPXKZZURYAXZQE-UHFFFAOYSA-N
SMILES
CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C2=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.73 | 100 | |
| Ethanol | 40.73 | 100 |
Preparing Stock Solutions
for LY 266097 hydrochloride
The following data is based on the product molecular weight 407.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.28 mL | 24.55 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Auclair The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens DArgic pathway activity. J.Neurochem. 2010 PMID: 20534001
- Audia Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus. J.Med.Chem. 1996 PMID: 8709108
Product Specific Notices for LY 266097 hydrochloride
For research use only
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