LY 255283

Name: LY 255283
Brand: Tocris Bioscience
SKU: 2208

Tocris Bioscience, part of Bio-Techne | Catalog # 2208

Citations (10)

COA / SDS

Selective, competitive BLT2 receptor antagonist

Key Product Details

Description:	Selective, competitive BLT₂ receptor antagonist
Chemical Name:	1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Purity:	≥98% (HPLC)
Molecular Weight:	360.46

View Full Technical Details for LY 255283

Technical Data
Citations

Biological Activity for LY 255283

LY 255283 is a selective, competitive antagonist of BLT₂ receptors (IC₅₀ values are ~ 1 and > 10 μM at human recombinant BLT₂ and BLT₁ receptors respectively). Inhibits LTB₄-induced contraction of lung parenchyma (pA₂ = 7.2), and reduces LTB₄-mediated airway obstruction in guinea pigs following i.v. and oral administration..

Compound Libraries for LY 255283

LY 255283 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 255283

M. Wt	360.46
Formula	C₁₉H₂₈N₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	117690-79-6
PubChem ID	122023
InChi Key	WCGXJPFHTHQNJL-UHFFFAOYSA-N
Smiles	CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 255283

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.05	100
	ethanol	9.01	25

Preparing Stock Solutions for LY 255283

The following data is based on the product molecular weight 360.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.74 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for LY 255283

References are publications that support the biological activity of the product.

Silbaugh Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 1992 PMID: 1335877
Yokomizo Hydroxyeicosanoids bind to and activate the low affinity leukotriene B₄ receptor, BLT2. J.Biol.Chem. 2001 PMID: 11278893
Herron Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 1992 PMID: 1316967