LY 2389575 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4969

Selective negative allosteric modulator of mGlu3 receptors
Discontinued Product
4969 has been discontinued. View all Group II mGluR Modulators products.

Key Product Details

Description

Selective negative allosteric modulator of mGlu3 receptors

View all Group II mGluR Modulators »

Product Description

LY 2389575 hydrochloride is a selective negative allosteric modulator of mGlu3 (IC50 = 190 nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.

Product Specifications

Molecular Weight

438.58

Formula

C15H15BrCl2N4.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride

CAS Number

885104-09-6

PubChem ID

11503054

InChI Key

IRIBLLOEUZMCQY-ZOWNYOTGSA-N

SMILES

ClC1=CC(Cl)=CC=C1CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.77 20

Preparing Stock Solutions for LY 2389575 hydrochloride

The following data is based on the product molecular weight 438.58

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.40 mL 57.00 mL 114.00 mL
1 mM 2.28 mL 11.40 mL 22.80 mL
2 mM 1.14 mL 5.70 mL 11.40 mL
10 mM 0.23 mL 1.14 mL 2.28 mL

Calculators

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Product Documents for LY 2389575 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 2389575 hydrochloride

For research use only

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