LY 215840
Tocris Bioscience, part of Bio-Techne | Catalog # 1523
5-HT2/5-HT7 antagonist
Discontinued Product
1523 has been discontinued.
View all Non-selective 5-HT Receptor Antagonists products.
Key Product Details
Description
5-HT2/5-HT7 antagonist
Product Description
LY 215840 is a 5-HT2/5-HT7 receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pKB = 8.26).Product Specifications
Molecular Weight
395.54
Formula
C24H33N3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
[8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide
CAS Number
137328-52-0
PubChem ID
9822062
InChI Key
IMSDOBUYDTVEHN-ILMFXRJHSA-N
SMILES
CC(C)N2C1=C(C(C[C@]4([H])[C@@]([H])3C[C@@H]([C@@](N[C@@H]5[C@H](O)CCC5)=O)CN4C)=C2)C3=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.55 | 100 | |
| Ethanol | 9.89 | 25 |
Preparing Stock Solutions
for LY 215840
The following data is based on the product molecular weight 395.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.28 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lenglet Activation of 5-HT7 receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. Endocrinology 2002 PMID: 11956157
- Louiset Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome. J.Clin.Endocrinol.Metab. 2006 PMID: 16954157
- Cushing LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J.Pharmacol.Exp.Ther. 1996 PMID: 8667223
Product Specific Notices for LY 215840
For research use only
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