LY 215840

Name: LY 215840
Brand: Tocris Bioscience
SKU: 1523
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1523

(1)

Citations (11)

COA / SDS

5-HT2/5-HT7 antagonist

Discontinued Product

1523 has been discontinued. View all Non-selective 5-HT Receptor Antagonists products.

Key Product Details

Description:	5-HT₂/5-HT₇ antagonist
Chemical Name:	[8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	395.54

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Technical Data
Citations / Reviews (1)

Biological Activity for LY 215840

LY 215840 is a 5-HT₂/5-HT₇ receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pK_B = 8.26).

Technical Data for LY 215840

M. Wt	395.54
Formula	C₂₄H₃₃N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	137328-52-0
PubChem ID	9822062
InChi Key	IMSDOBUYDTVEHN-ILMFXRJHSA-N
Smiles	CC(C)N2C1=C(C(C[C@]4([H])[C@@]([H])3C[C@@H]([C@@](N[C@@H]5[C@H](O)CCC5)=O)CN4C)=C2)C3=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 215840

References are publications that support the biological activity of the product.

Lenglet Activation of 5-HT₇ receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. Endocrinology 2002 PMID: 11956157
Louiset Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome. J.Clin.Endocrinol.Metab. 2006 PMID: 16954157
Cushing LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J.Pharmacol.Exp.Ther. 1996 PMID: 8667223

LY 215840

Tocris Bioscience, part of Bio-Techne | Catalog # 1523

Key Product Details

Biological Activity for LY 215840

Technical Data for LY 215840

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LY 215840

Product Documents for LY 215840

COA

Certificate of Analysis

SDS

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