LTURM 34
Tocris Bioscience, part of Bio-Techne | Catalog # 5834
Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency
Key Product Details
Description
Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency
Product Description
LTURM 34 is a potent DNA-PK inhibitor (IC50 = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro. LTURM 34 also increases CRISPR-Cas9 deletion efficiency.Product Specifications
Molecular Weight
414.48
Formula
C24H18N2O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
CAS Number
1879887-96-3
PubChem ID
122705987
InChI Key
SMMSWOMXOZLOPI-UHFFFAOYSA-N
SMILES
O=C1C2=C(C(C3=CC=CC4=C3SC5=C4C=CC=C5)=CC=C2)OC(N6CCOCC6)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.72 | 50 |
Preparing Stock Solutions
for LTURM 34
The following data is based on the product molecular weight 414.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.83 mL | 24.13 mL | 48.25 mL |
| 2.5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 25 mM | 0.10 mL | 0.48 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bosch-Guiteras Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs. Genome Res. 2021 PMID: 33574136
- Morrison Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 2016 PMID: 26854431
Product Specific Notices for LTURM 34
For research use only
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