LTURM 34

Name: LTURM 34
Brand: Tocris Bioscience
SKU: 5834

Tocris Bioscience, part of Bio-Techne | Catalog # 5834

COA / SDS

Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency

Key Product Details

Description:	Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency
Chemical Name:	8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	414.48

View Full Technical Details for LTURM 34

Technical Data
Citations

Biological Activity for LTURM 34

LTURM 34 is a potent DNA-PK inhibitor (IC₅₀ = 34 nM). Exhibits 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro. LTURM 34 also increases CRISPR-Cas9 deletion efficiency.

Technical Data for LTURM 34

M. Wt	414.48
Formula	C₂₄H₁₈N₂O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1879887-96-3
PubChem ID	122705987
InChi Key	SMMSWOMXOZLOPI-UHFFFAOYSA-N
Smiles	O=C1C2=C(C(C3=CC=CC4=C3SC5=C4C=CC=C5)=CC=C2)OC(N6CCOCC6)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LTURM 34

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.72	50

Preparing Stock Solutions for LTURM 34

The following data is based on the product molecular weight 414.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.83 mL	24.13 mL	48.25 mL
2.5 mM	0.97 mL	4.83 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

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References for LTURM 34

References are publications that support the biological activity of the product.

Bosch-Guiteras Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs. Genome Res. 2021 PMID: 33574136
Morrison Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur.J.Med.Chem. 2016 PMID: 26854431