LTGO-33

Name: LTGO-33
Brand: Tocris Bioscience
SKU: 8865

Tocris Bioscience, part of Bio-Techne | Catalog # 8865

COA / SDS

Potent and selective state-independent inhibitor of NaV1.8 sodium channels

Key Product Details

Description:	Potent and selective state-independent inhibitor of Na_V1.8 sodium channels
Chemical Name:	(R)-2-(4-Fluoro-2-methylphenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide
Purity:	≥98% (HPLC)
Molecular Weight:	467.44

View Full Technical Details for LTGO-33

Technical Data
Citations

Biological Activity for LTGO-33

LTGO-33 is a potent and selective state-independent inhibitor of Na_V1.8 sodium channels (IC₅₀ = 13 nM for the closed state; IC₅₀ = 24 nM for the inactive state). It displays 600-fold selectivity over other sodium channels such as Na_V1.1-1.7 and Na_V1.9. By binding to Na_V1.8 channels, LTGO-33 inhibits action potential initiation and transmission of pain signals in human DRG neurons. Unlike other Na_V1.8 inhibitors that preferentially interact with an inactivated state via the pore region, LTGO-33 is state-independent with similar potencies against closed and inactivated channels.

Licensing Information

Sold with kind permission of Latigo Biotherapeutics

Technical Data for LTGO-33

M. Wt	467.44
Formula	C₂₁H₁₇F₄N₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2834106-06-6
PubChem ID	169124157
InChi Key	IIJWTXGHWFZLBF-JGCGQSQUSA-N
Smiles	N=[S@](C1=CC=CC(NC(C2=C(N=CC(C(F)(F)F)=C2)OC3=C(C=C(C=C3)F)C)=O)=C1)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LTGO-33

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.74	100
	ethanol	46.74	100

Preparing Stock Solutions for LTGO-33

The following data is based on the product molecular weight 467.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.70 mL	21.39 mL
5 mM	0.43 mL	2.14 mL	4.28 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for LTGO-33

References are publications that support the biological activity of the product.

Gilchrist Pharmacologic characterization of LTGO-33, a selective small molecule inhibitor of the voltage-gated sodium channel NaV1.8 with a unique mechanism of action. Mol.Pharmacol 2024 PMID: 38195157