Lonidamine

Name: Lonidamine
Brand: Tocris Bioscience
SKU: 1646

Tocris Bioscience, part of Bio-Techne | Catalog # 1646

Citations (17)

COA / SDS

Mitochondrial hexokinase inhibitor

Key Product Details

Description:	Mitochondrial hexokinase inhibitor
Alternative Names:	AF 1890
Chemical Name:	1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	321.16

View Full Technical Details for Lonidamine

Technical Data
Citations

Biological Activity for Lonidamine

Lonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl^- channels in vitro.

Compound Libraries for Lonidamine

Lonidamine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Lonidamine

M. Wt	321.16
Formula	C₁₅H₁₀Cl₂N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	50264-69-2
PubChem ID	39562
InChi Key	WDRYRZXSPDWGEB-UHFFFAOYSA-N
Smiles	OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lonidamine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	1.61	5
	DMSO	32.12	100

Preparing Stock Solutions for Lonidamine

The following data is based on the product molecular weight 321.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.11 mL	15.57 mL	31.14 mL
5 mM	0.62 mL	3.11 mL	6.23 mL
10 mM	0.31 mL	1.56 mL	3.11 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Molarity Calculator

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Reconstitution Calculator

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References for Lonidamine

References are publications that support the biological activity of the product.

Teiche Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 1994 PMID: 7833093
Gong Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 2002 PMID: 12411425
Lobl Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 1981 PMID: 6793318
De Martino Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 1984 PMID: 6717891