Lomitapide mesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 7492
Potent microsomal triglyceride transfer protein (MTP) inhibitor
Key Product Details
Description
Potent microsomal triglyceride transfer protein (MTP) inhibitor
Product Description
Lomitapide mesylate is a potent inhibitor of microsomal triglyceride transfer protein (IC50 = 8 nM). Lomitapide inhibits or normalizes lipoprotein production in rodents and in a rabbit model of hypercholesterolemia. Lomitapide is antimalarial; it inhibits hemozoin formation and growth of CQ-sensitive (PfNF54) and multidrug-resistant (PfK1) strains of P. falciparum (IC50 values are 0.56 µM and 0.69 µM respectively). Orally bioavailable.Product Specifications
Molecular Weight
789.83
Formula
C39H37F6N3O2.CH3SO3H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate
CAS Number
2059395-52-5
PubChem ID
11274333
InChI Key
QKVKOFVWUHNEBX-UHFFFAOYSA-N
SMILES
O=C(C1=C(C2=CC=C(C(F)(F)F)C=C2)C=CC=C1)NC3CCN(CC3)CCCCC4(C5=C(C6=C4C=CC=C6)C=CC=C5)C(NCC(F)(F)F)=O.CS(O)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.8 | 20 | |
| Ethanol | 7.9 | 10 |
Preparing Stock Solutions
for Lomitapide mesylate
The following data is based on the product molecular weight 789.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 6.33 mL | 31.65 mL | 63.30 mL |
| 1 mM | 1.27 mL | 6.33 mL | 12.66 mL |
| 2 mM | 0.63 mL | 3.17 mL | 6.33 mL |
| 10 mM | 0.13 mL | 0.63 mL | 1.27 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Robl A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. J.Med.Chem. 2001 PMID: 11300866
- Sousa Lapatinib, Nilotinib and Lomitapide inhibit haemozoin formation in malaria parasites. Molecules 2020 PMID: 32235391
- Wetterau An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 1998 PMID: 9784135
Product Specific Notices for Lomitapide mesylate
For research use only
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