LM 22A4
Tocris Bioscience, part of Bio-Techne | Catalog # 4607
Potent TrkB agonist
Product Description
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum and exhibits neurotrophic activity. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.Product Specifications
Molecular Weight
339.34
Formula
C15H21N3O6
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
CAS Number
37988-18-4
PubChem ID
2054170
InChI Key
RGWJKANXFYJKHN-UHFFFAOYSA-N
SMILES
O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.93 | 100 | |
| DMSO | 33.93 | 100 |
Preparing Stock Solutions
for LM 22A4
The following data is based on the product molecular weight 339.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.47 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schmid A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 2012 PMID: 22302819
- Massa Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 2010 PMID: 20407211
Product Specific Notices for LM 22A4
For research use only
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