LJI308

Name: LJI308
Brand: Tocris Bioscience
SKU: 6754

Tocris Bioscience, part of Bio-Techne | Catalog # 6754

COA / SDS

Potent pan-RSK inhibitor

Key Product Details

Description:	Potent pan-RSK inhibitor
Chemical Name:	2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol
Purity:	≥98% (HPLC)
Molecular Weight:	368.38

View Full Technical Details for LJI308

Technical Data
Citations

Biological Activity for LJI308

LJI308 is a potent pan-ribosomal S6 protein kinase (RSK) inhibitor (IC₅₀ values are 4 to 13 nM). Displays selectivity for RSK isoforms over other kinases. Inhibits RSK-dependent Y-box binding protein 1 (YB-1) phosphorylation in vitro. Suppresses growth of triple negative breast cancer cell lines.

Compound Libraries for LJI308

LJI308 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LJI308

M. Wt	368.38
Formula	C₂₁H₁₈F₂N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1627709-94-7
PubChem ID	118704762
InChi Key	YUYJEQHNWKQNBT-UHFFFAOYSA-N
Smiles	OC1=C(C=C(C2=CN=CC=C2C3=CC=C(N4CCOCC4)C=C3)C=C1F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LJI308

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.42	50

Preparing Stock Solutions for LJI308

The following data is based on the product molecular weight 368.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.43 mL	27.15 mL	54.29 mL
2.5 mM	1.09 mL	5.43 mL	10.86 mL
5 mM	0.54 mL	2.71 mL	5.43 mL
25 mM	0.11 mL	0.54 mL	1.09 mL

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References for LJI308

References are publications that support the biological activity of the product.

Aronchik Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol.Cancer Res. 2014 PMID: 24554780
Davies Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 2015 PMID: 26011941
Jain Discovery of potent and selective RSK inhibitors as biological probes. J.Med.Chem. 2015 PMID: 26270416