LJI308

Tocris Bioscience, part of Bio-Techne | Catalog # 6754

Potent pan-RSK inhibitor
Catalog #
Availability
Size / Price
Qty
6754/25
6754/5
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Potent pan-RSK inhibitor

View all RSK Inhibitors »

Product Description

LJI308 is a potent pan-ribosomal S6 protein kinase (RSK) inhibitor (IC50 values are 4 to 13 nM). Displays selectivity for RSK isoforms over other kinases. Inhibits RSK-dependent Y-box binding protein 1 (YB-1) phosphorylation in vitro. Suppresses growth of triple negative breast cancer cell lines.

Product Specifications

Molecular Weight

368.38

Formula

C21H18F2N2O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol

CAS Number

1627709-94-7

PubChem ID

118704762

InChI Key

YUYJEQHNWKQNBT-UHFFFAOYSA-N

SMILES

OC1=C(C=C(C2=CN=CC=C2C3=CC=C(N4CCOCC4)C=C3)C=C1F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.42 50

Preparing Stock Solutions for LJI308

The following data is based on the product molecular weight 368.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.43 mL 27.15 mL 54.29 mL
2.5 mM 1.09 mL 5.43 mL 10.86 mL
5 mM 0.54 mL 2.71 mL 5.43 mL
25 mM 0.11 mL 0.54 mL 1.09 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for LJI308

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LJI308

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.