LG 101506

Name: LG 101506
Brand: Tocris Bioscience
SKU: 3508

Tocris Bioscience, part of Bio-Techne | Catalog # 3508

Citations (3)

COA / SDS

Selective RXR modulator

Discontinued Product

3508 has been discontinued. View all Retinoid X Receptor Modulators products.

Key Product Details

Description:	Selective RXR modulator
Alternative Names:	LG 1506
Chemical Name:	(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	420.53

View Full Technical Details for LG 101506

Technical Data
Citations

Biological Activity for LG 101506

LG 101506 is a selective RXR modulator (K_i values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (K_i values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.

Technical Data for LG 101506

M. Wt	420.53
Formula	C₂₅H₃₄F₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	331248-11-4
PubChem ID	9845057
InChi Key	BHIBZAZKKARFIM-XRYBSMBUSA-N
Smiles	CC(C)(C)C1=CC(/C(C)=C\C=C\C(C)=C\C(O)=O)=C(OCC(F)F)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LG 101506

References are publications that support the biological activity of the product.

Leibowitz Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 2006 PMID: 16269450
Pinaire Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 2007 PMID: 17497022
Michellys Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 2003 PMID: 12801232

LG 101506

Tocris Bioscience, part of Bio-Techne | Catalog # 3508

Key Product Details

Biological Activity for LG 101506

Technical Data for LG 101506

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LG 101506

Product Documents for LG 101506

COA

Certificate of Analysis

SDS

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