LG 100268
Tocris Bioscience, part of Bio-Techne | Catalog # 5920
Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers
Key Product Details
Description
Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers
Product Description
LG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC50 = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.Product Specifications
Molecular Weight
363.49
Formula
C24H29NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid
CAS Number
153559-76-3
PubChem ID
3922
InChI Key
SLXTWXQUEZSSTJ-UHFFFAOYSA-N
SMILES
CC1=C(C2(C3=CC=C(C(O)=O)C=N3)CC2)C=C4C(C(C)(CCC4(C)C)C)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.17 | 50 |
Preparing Stock Solutions
for LG 100268
The following data is based on the product molecular weight 363.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.50 mL | 27.51 mL | 55.02 mL |
| 2.5 mM | 1.10 mL | 5.50 mL | 11.00 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.50 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.10 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Boehm Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 1995 PMID: 7636877
- Lala Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 PMID: 8837780
Product Specific Notices for LG 100268
For research use only
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