LDN 27219

Name: LDN 27219
Brand: Tocris Bioscience
SKU: 4602

Tocris Bioscience, part of Bio-Techne | Catalog # 4602

Citations (8)

COA / SDS

Transglutaminase 2 (TG2) inhibitor; reversible

Discontinued Product

4602 has been discontinued. View all Additional Transferase Products products.

Key Product Details

Description:	Transglutaminase 2 (TG2) inhibitor; reversible
Chemical Name:	2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]acetic acid hydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	408.5

View Full Technical Details for LDN 27219

Technical Data
Citations

Biological Activity for LDN 27219

LDN 27219 is a transglutaminase 2 (TG2) inhibitor (IC₅₀ = 0.25 μM). Binds at GTPase site; reversible.

Compound Libraries for LDN 27219

LDN 27219 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LDN 27219

M. Wt	408.5
Formula	C₂₀H₁₆N₄O₂S₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	312946-37-5
PubChem ID	1150683
InChi Key	WLBUICQBNZXIDJ-UHFFFAOYSA-N
Smiles	O=C(NN)CSC(N1C2=CC=CC=C2)=NC3=C(C(C4=CC=CC=C4)=CS3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LDN 27219

References are publications that support the biological activity of the product.

Prime Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J.Med.Chem. 2012 PMID: 22224594
Duval Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15780627
Case and Stein Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 2007 PMID: 17240993