LDN 193188
Tocris Bioscience, part of Bio-Techne | Catalog # 5631
Inhibitor of phosphatidylcholine transfer protein (PC-TP)
Key Product Details
Description
Inhibitor of phosphatidylcholine transfer protein (PC-TP)
Product Description
LDN 193188 is an inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.Product Specifications
Molecular Weight
494.35
Formula
C20H17Cl2N5O4S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
CAS Number
1267610-30-9
PubChem ID
66958626
InChI Key
COTBDKMEUUNJTI-UHFFFAOYSA-N
SMILES
O=C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=O)C3=C(Cl)C=C(Cl)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.44 | 100 |
Preparing Stock Solutions
for LDN 193188
The following data is based on the product molecular weight 494.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.11 mL | 20.23 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.05 mL |
| 10 mM | 0.20 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wagle Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 2008 PMID: 18762160
- Shishova Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 2011 PMID: 21538437
Product Specific Notices for LDN 193188
For research use only
Loading...
Loading...