Lazabemide hydrochloride

Name: Lazabemide hydrochloride
Brand: Tocris Bioscience
SKU: 2460

Tocris Bioscience, part of Bio-Techne | Catalog # 2460

Citations (3)

COA / SDS

Selective MAO-B inhibitor

Key Product Details

Description:	Selective MAO-B inhibitor
Alternative Names:	Ro 19-6327
Chemical Name:	N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	236.1

View Full Technical Details for Lazabemide hydrochloride

Technical Data
Citations

Biological Activity for Lazabemide hydrochloride

Lazabemide hydrochloride is a selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀ values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC₅₀ values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).

Technical Data for Lazabemide hydrochloride

M. Wt	236.1
Formula	C₈H₁₀ClN₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	103878-83-7
PubChem ID	163727
InChi Key	JMFKTFLARGGXCC-UHFFFAOYSA-N
Smiles	Cl.NCCNC(=O)C1=NC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lazabemide hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.61	100
	water	23.61	100

Preparing Stock Solutions for Lazabemide hydrochloride

The following data is based on the product molecular weight 236.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.24 mL	21.18 mL	42.35 mL
5 mM	0.85 mL	4.24 mL	8.47 mL
10 mM	0.42 mL	2.12 mL	4.24 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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References for Lazabemide hydrochloride

References are publications that support the biological activity of the product.

Bondiolotti In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 1995 PMID: 7605351
Guimaraes and Soares-da-Silva The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998 PMID: 9489509
Saura Quantitative enzyme radioautography with ³H-Ro 41-1049 and ³H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 1992 PMID: 1578281