Latrunculin B
Tocris Bioscience, part of Bio-Techne | Catalog # 3974
Inhibitor of actin polymerization
Product Description
Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC50 values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.Product Specifications
Molecular Weight
395.51
Formula
C20H29NO5S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
CAS Number
76343-94-7
PubChem ID
3892
InChI Key
NSHPHXHGRHSMIK-UHFFFAOYSA-N
SMILES
O=C1/C=C(C)\CC/C=C\[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.78 | 50 | |
| Ethanol | 19.78 | 50 |
Preparing Stock Solutions
for Latrunculin B
The following data is based on the product molecular weight 395.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.06 mL | 25.28 mL | 50.57 mL |
| 2.5 mM | 1.01 mL | 5.06 mL | 10.11 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 25 mM | 0.10 mL | 0.51 mL | 1.01 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wakatsuki Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J.Cell.Sci. 2001 PMID: 11181185
Product Specific Notices for Latrunculin B
For research use only
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