Latrunculin A

Tocris Bioscience, part of Bio-Techne | Catalog # 3973

Inhibitor of actin assembly and polymerization
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Key Product Details

Description

Inhibitor of actin assembly and polymerization

Alternative Names

LAT-A

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Product Description

Latrunculin A (LAT-A) is a marine toxin that binds ATP-actin (Kd = 0.1 µM), G-actin (Kd = 0.19 µM), ADP-Pi-actin (Kd = 0.4 µM) and ADP-actin (Kd = 4.7 µM) monomers in cells. By binding and sequestering actin monomers and preventing F-actin filament formation, LAT-A inhibits actin polymerization without significant direct effects on microtubules or other cytoskeletal components. Latrunculin A can be used to transiently disrupt the actin cytoskeleton to investigate actin-dependent cellular functions including motility, shape maintenance, intracellular trafficking, and mechanotransduction. Latrunculin A displays anti-invasive activity against human prostate cancer cells and suppresses hypoxia-induced HIF-1 activation in breast tumour cells in vitro. Latrunculin A is also a potent inhibitor of phagocytosis by macrophages.In vivo, it has been used in various model organisms to study cytoskeletal dynamics affecting processes such as cancer cell migration and morphogenesis. LAT-A has strong antitumor effect in mice models infected with adenocarcinoma or carcinoma.

This product is typically reconstituted in DMSO as a primary solvent.

Product Specifications

Molecular Weight

421.55

Formula

C22H31NO5S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

CAS Number

76343-93-6

PubChem ID

445420

InChI Key

DDVBPZROPPMBLW-IZGXTMSKSA-N

SMILES

C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Latrunculin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Latrunculin A

For research use only

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