Lalistat 1

Name: Lalistat 1
Brand: Tocris Bioscience
SKU: 6098
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6098

Citations (13)

COA / SDS

Potent and selective LAL inhibitor

Key Product Details

Description:	Potent and selective LAL inhibitor
Chemical Name:	4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	298.36

View Full Technical Details for Lalistat 1

Technical Data
Citations

Biological Activity for Lalistat 1

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC₅₀ = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

Compound Libraries for Lalistat 1

Lalistat 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Lalistat 1

M. Wt	298.36
Formula	C₁₂H₁₈N₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	501104-16-1
PubChem ID	648404
InChi Key	GKOPFXFKPASEFI-UHFFFAOYSA-N
Smiles	O=C(OC1=NSN=C1N2CCCCC2)N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lalistat 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.84	100
	ethanol	29.84	100

Preparing Stock Solutions for Lalistat 1

The following data is based on the product molecular weight 298.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for Lalistat 1

References are publications that support the biological activity of the product.

Ouimet Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011 PMID: 21641547
Rosenbaum Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 2010 PMID: 20557099
Rosenbaum Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 2009 PMID: 19699313