L-NMMA acetate
Tocris Bioscience, part of Bio-Techne | Catalog # 0771
Non-selective NOS inhibitor
Discontinued Product
0771 has been discontinued.
View all Additional NOS Inhibitors products.
Product Description
L-NMMA acetate is a competitive, irreversible inhibitor of all three NOS isoforms.Product Specifications
Molecular Weight
248.28
Formula
C7H16N4O2.CH3CO2H
Storage
Desiccate at RT
Chemical Name
NG-Monomethyl-L-arginine acetate
CAS Number
53308-83-1
PubChem ID
135242
InChI Key
IKPNWIGTWUZCKM-JEDNCBNOSA-N
SMILES
CC(O)=O.N=C(NCCC[C@H](N)C(O)=O)NC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 12.41 | 50 |
Preparing Stock Solutions
for L-NMMA acetate
The following data is based on the product molecular weight 248.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.06 mL | 40.28 mL | 80.55 mL |
| 2.5 mM | 1.61 mL | 8.06 mL | 16.11 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 25 mM | 0.16 mL | 0.81 mL | 1.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Saksuma Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 1988 PMID: 3263652
- Rees Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 1990 PMID: 1706208
- Reif and McCreedy N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 1995 PMID: 7540822
- Olken Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 1991 PMID: 2049105
Product Specific Notices for L-NMMA acetate
For research use only
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