L-817,818

Tocris Bioscience, part of Bio-Techne | Catalog # 1980

Potent and selective sst5 agonist
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1980/10
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Key Product Details

Description

Potent and selective sst5 agonist

View all Somatostatin Receptor Agonists »

Product Description

L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.

Product Specifications

Molecular Weight

536.67

Formula

C33H36N4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester

CAS Number

217480-27-8

PubChem ID

9937014

InChI Key

NFVRGDRCCNEGBS-KCWXNJEJSA-N

SMILES

O=C(CC1=C(C4=CC=C(C=CC=C5)C5=C4)NC2=C1C=CC3=C2C=CC=C3)N[C@@H]([C@](OC[C@@H](N)C)=O)CCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.67 100

Preparing Stock Solutions for L-817,818

The following data is based on the product molecular weight 536.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.32 mL 18.63 mL
5 mM 0.37 mL 1.86 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for L-817,818

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-817,818

For research use only

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