L-745,870 trihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1002
Highly selective D4 antagonist
Key Product Details
Description
Highly selective D4 antagonist
Product Description
L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
436.21
Formula
C18H19N4Cl.3HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
CAS Number
866021-03-6
PubChem ID
49759035
InChI Key
KJSOYZLYCFYXFC-UHFFFAOYSA-N
SMILES
Cl.Cl.Cl.ClC1=CC=C(C=C1)N1CCN(CC2=CNC3=NC=CC=C23)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.62 | 100 |
Preparing Stock Solutions
for L-745,870 trihydrochloride
The following data is based on the product molecular weight 436.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.46 mL | 22.92 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pillai Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect Neuropharmacology 1998 PMID: 9833627
- Kulagowski 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human D4 receptor. J.Med.Chem. 1996 PMID: 8642550
- Patel Biological profile of L-745,870, a selective antagonist with high affinity for the DA D4 receptor. J.Pharmacol.Exp.Ther. 1997 PMID: 9353380
- Bristow Schizophrenia and L-745, 870 a novel DA D4 receptor antagonist. TiPS 1997 PMID: 9226994
Product Specific Notices for L-745,870 trihydrochloride
For research use only
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