L-655,708

Tocris Bioscience, part of Bio-Techne | Catalog # 1327

Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors
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Key Product Details

Description

Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors

View all Benzodiazepine Inverse Agonists »

Product Description

L-655,708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Product Specifications

Molecular Weight

341.37

Formula

C18H19N3O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

CAS Number

130477-52-0

PubChem ID

5311203

InChI Key

YKYOQIXTECBVBB-AWEZNQCLSA-N

SMILES

O=C(N3[C@]([H])2CCC3)C4=C(C=CC(OC)=C4)N1C2=C(C(OCC)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.53 25

Preparing Stock Solutions for L-655,708

The following data is based on the product molecular weight 341.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.72 mL 58.59 mL 117.17 mL
1.25 mM 2.34 mL 11.72 mL 23.43 mL
2.5 mM 1.17 mL 5.86 mL 11.72 mL
12.5 mM 0.23 mL 1.17 mL 2.34 mL

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Product Documents for L-655,708

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-655,708

For research use only

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