L-365,260
Tocris Bioscience, part of Bio-Techne | Catalog # 2767
Selective CCK2 antagonist
Product Description
L-365,260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.Product Specifications
Molecular Weight
398.46
Formula
C24H22N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
CAS Number
118101-09-0
PubChem ID
5311201
InChI Key
KDFQABSFVYLGPM-QFIPXVFZSA-N
SMILES
O=C1[C@H](NC(NC4=CC=CC(C)=C4)=O)N=C(C3=CC=CC=C3)C2=C(C=CC=C2)N1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.85 | 100 | |
| Ethanol | 39.85 | 100 |
Preparing Stock Solutions
for L-365,260
The following data is based on the product molecular weight 398.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.10 mL |
| 5 mM | 0.50 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lotti and Chang A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 1989 PMID: 2721567
- Chung Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 2009 PMID: 19497313
- Kees Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 1989 PMID: 2909725
Product Specific Notices for L-365,260
For research use only
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