KYP 2047

Name: KYP 2047
Brand: Tocris Bioscience
SKU: 6272

Tocris Bioscience, part of Bio-Techne | Catalog # 6272

Citations (1)

COA / SDS

High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant

Key Product Details

Description:	High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant
Chemical Name:	(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	339.44

View Full Technical Details for KYP 2047

Technical Data
Citations

Biological Activity for KYP 2047

KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (K_i = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia. In vivo, treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.

Technical Data for KYP 2047

M. Wt	339.44
Formula	C₂₀H₂₅N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	796874-99-2
PubChem ID	11198569
InChi Key	SPXFAUXQZWJGCJ-ROUUACIJSA-N
Smiles	O=C(N1CCC[C@H]1C#N)[C@@H]2CCCN2C(CCCC3=CC=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KYP 2047

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.94	100
	ethanol	16.97	50

Preparing Stock Solutions for KYP 2047

The following data is based on the product molecular weight 339.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.73 mL	29.46 mL
5 mM	0.59 mL	2.95 mL	5.89 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for KYP 2047

References are publications that support the biological activity of the product.

Eteläinen A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Sci.Transl.Med. 2023 PMID: 37043557
Venäläinen Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors. Biochem.Pharmacol. 2006 PMID: 16405869
Myöhänen Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. Br.J.Pharmacol. 2011 PMID: 21133893
Jalkanen Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat. Basic Clin.Pharmacol.Toxicol. 2011 PMID: 21707925
Myöhänen A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. Br.J.Pharmacol. 2012 PMID: 22233220
Yedlapudi Inhibition of alpha-synuclein aggregation by multifunctional Da agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model. Sci Rep. 2016 PMID: 27917933