KW 3902
Tocris Bioscience, part of Bio-Techne | Catalog # 4167
Selective A1 antagonist
Key Product Details
Description
Selective A1 antagonist
Alternative Names
Rolofylline
Product Description
KW 3902 is a selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.Product Specifications
Molecular Weight
356.46
Formula
C20H28N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
CAS Number
136199-02-5
PubChem ID
64627
InChI Key
PJBFVWGQFLYWCB-UHFFFAOYSA-N
SMILES
O=C1C2=C(NC(C34CC(CC4C5)CC5C3)=N2)N(CCC)C(N1CCC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.82 | 50 | |
| Ethanol | 8.91 | 25 |
Preparing Stock Solutions
for KW 3902
The following data is based on the product molecular weight 356.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.61 mL | 28.05 mL | 56.11 mL |
| 2.5 mM | 1.12 mL | 5.61 mL | 11.22 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nonaka KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br.J.Pharmacol. 1996 PMID: 8732272
- Nishiyama Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction. J.Pharmacol.Exp.Ther. 1999 PMID: 10565815
- Shimada 8-polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. J.Med.Chem. 1992 PMID: 1548682
Product Specific Notices for KW 3902
For research use only
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