KML 29
Tocris Bioscience, part of Bio-Techne | Catalog # 4872
Highly potent and selective MAGL inhibitor
Key Product Details
Description
Highly potent and selective MAGL inhibitor
Product Description
KML 29 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).Licensing Information
Sold under license from The Scripps Research InstituteProduct Specifications
Molecular Weight
549.42
Formula
C24H21F6NO7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CAS Number
1380424-42-9
PubChem ID
71656212
InChI Key
SXHQLPHDBLTFPM-UHFFFAOYSA-N
SMILES
O=C(OC(C(F)(F)F)C(F)(F)F)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)(O)C1=CC(OCO4)=C4C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.94 | 100 |
Preparing Stock Solutions
for KML 29
The following data is based on the product molecular weight 549.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.82 mL | 9.10 mL | 18.20 mL |
| 5 mM | 0.36 mL | 1.82 mL | 3.64 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.82 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chang Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 2012 PMID: 22542104
- Ueda Discrimination between two endocannabinoids. Chem.Biol. 2012 PMID: 22633404
Product Specific Notices for KML 29
For research use only
Loading...
Loading...