KL 465
Tocris Bioscience, part of Bio-Techne | Catalog # 8854
MAGE-A3 Degrader (PROTAC®)
Product Description
KL 465 is a MAGE-A3 Degrader (PROTAC®) (DC50 = 2 μM; Dmax = 60%). MAGE-A3 degradation with KL 465 decreases cancer cell viability and is VHL dependent.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1021.20
Formula
C56H60N8O9S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-N-(2-(2-(2-(2-((4-(Furan-2-carbonyl)piperazin-1-yl)methyl)-4-(1H-indazol-4-yl)phenoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide
CAS Number
3057446-82-6
InChI Key
MQOTXOOWIOCPNH-IYCLWVRSSA-N
SMILES
O=C(C1=CC=CO1)N2CCN(CC2)CC3=CC(C4=CC=CC5=C4C=NN5)=CC=C3OCCOCCOC6=CC(C7=C(N=CS7)C)=CC=C6CNC([C@@H]8C[C@H](CN8C([C@H](C(C)C)N9CC%10=C(C9=O)C=CC=C%10)=O)O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.06 | 50 |
Preparing Stock Solutions
for KL 465
The following data is based on the product molecular weight 1021.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.96 mL | 9.79 mL | 19.58 mL |
| 2.5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 5 mM | 0.20 mL | 0.98 mL | 1.96 mL |
| 25 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Development of ligands and degraders targeting MAGE-A3. J.Am.Chem.Soc. 2024 PMID: 39190582
Product Specific Notices for KL 465
For research use only
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