KJ Pyr 9

Name: KJ Pyr 9
Brand: Tocris Bioscience
SKU: 5306

Tocris Bioscience, part of Bio-Techne | Catalog # 5306

Citations (6)

COA / SDS

High affinity Myc inhibitor

Key Product Details

Description:	High affinity Myc inhibitor
Chemical Name:	4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	385.37

View Full Technical Details for KJ Pyr 9

Technical Data
Citations

Biological Activity for KJ Pyr 9

KJ Pyr 9 is a high affinity Myc inhibitor (K_d = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.

Technical Data for KJ Pyr 9

M. Wt	385.37
Formula	C₂₂H₁₅N₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	581073-80-5
PubChem ID	85855478
InChi Key	GTTDVYCKFQYVNN-UHFFFAOYSA-N
Smiles	O=C(N)C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KJ Pyr 9

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.54	100

Preparing Stock Solutions for KJ Pyr 9

The following data is based on the product molecular weight 385.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.97 mL	25.95 mL
5 mM	0.52 mL	2.59 mL	5.19 mL
10 mM	0.26 mL	1.30 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for KJ Pyr 9

References are publications that support the biological activity of the product.

Hart Inhibitor of MYC identified in a Kröhnke pyridine library. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 25114221