Kinesore
Tocris Bioscience, part of Bio-Techne | Catalog # 6664
Kinesin-1 modulator; cell permeable
Product Description
Kinesore is a kinesin-1 modulator. Inhibits SKIP-KLC2 interaction, but promotes kinesin-1 function in controlling the organization of the microtubule network. Induces remodeling of the microtubule network and the formation of extensive microtubule-rich projections. Cell permeable.Product Specifications
Molecular Weight
536.17
Formula
C20H16Br2N4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
CAS Number
363571-83-9
PubChem ID
5507411
InChI Key
DUGCMEGLYHBMAR-RMORIDSASA-N
SMILES
CC1=CC(/C=N/NC(C2=CC(Br)=C(C(Br)=C2)O)=O)=C(N1C3=CC([N+]([O-])=O)=CC=C3)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.62 | 100 |
Preparing Stock Solutions
for Kinesore
The following data is based on the product molecular weight 536.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.87 mL | 9.33 mL | 18.65 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.73 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.87 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Randall A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Proc.Natl.Acad.Sci.USA 2017 PMID: 29229862
Product Specific Notices for Kinesore
For research use only
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