KH 7
Tocris Bioscience, part of Bio-Techne | Catalog # 3834
Selective soluble adenylyl cyclase inhibitor
Key Product Details
Description
Selective soluble adenylyl cyclase inhibitor
Product Description
KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.Product Specifications
Molecular Weight
419.30
Formula
C17H15BrN4O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
CAS Number
330676-02-3
PubChem ID
6843191
InChI Key
GEHVZUUHMWNMAY-UHFFFAOYSA-N
SMILES
OC(C=CC(Br)=C2)=C2/C=N/NC(C(C)SC1=NC(C=CC=C3)=C3N1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.93 | 100 |
Preparing Stock Solutions
for KH 7
The following data is based on the product molecular weight 419.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.85 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stessin Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 2006 PMID: 16627466
- Hess The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Develop.Cell
- Kumar Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 2009 PMID: 19336406
Product Specific Notices for KH 7
For research use only
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