JZP 430
Tocris Bioscience, part of Bio-Techne | Catalog # 5844
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Key Product Details
Description
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Product Description
JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).Product Specifications
Molecular Weight
354.47
Formula
C16H26N4O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate
CAS Number
1672691-74-5
PubChem ID
121513897
InChI Key
WKSHMJCYWFOADB-UHFFFAOYSA-N
SMILES
O=C(N(C)C1CCCCCCC1)OC2=NSN=C2N3CCOCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.72 | 50 | |
| Ethanol | 7.09 | 20 |
Preparing Stock Solutions
for JZP 430
The following data is based on the product molecular weight 354.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.64 mL | 28.21 mL | 56.42 mL |
| 2.5 mM | 1.13 mL | 5.64 mL | 11.28 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.13 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Patel Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 2015 PMID: 25504894
Product Specific Notices for JZP 430
For research use only
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