JZL 184

Name: JZL 184
Brand: Tocris Bioscience
SKU: 3836

Tocris Bioscience, part of Bio-Techne | Catalog # 3836

Citations (100)

COA / SDS

Potent MAGL inhibitor

Key Product Details

Description:	Potent MAGL inhibitor
Chemical Name:	4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	520.49

View Full Technical Details for JZL 184

Technical Data
Citations

Biological Activity for JZL 184

JZL 184 is a potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC₅₀ = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries for JZL 184

JZL 184 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JZL 184

M. Wt	520.49
Formula	C₂₇H₂₄N₂O₉
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1101854-58-3
PubChem ID	25021165
InChi Key	SEGYOKHGGFKMCX-UHFFFAOYSA-N
Smiles	O=C(OC6=CC=C([N+]([O-])=O)C=C6)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)(O)C1=CC(OCO4)=C4C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JZL 184

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.05	100

Preparing Stock Solutions for JZL 184

The following data is based on the product molecular weight 520.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.92 mL	9.61 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL
10 mM	0.19 mL	0.96 mL	1.92 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for JZL 184

References are publications that support the biological activity of the product.

Zhang Dysregulated lipid metabolism in cancer. World J.Biol.Chem. 2012 PMID: 22937213
Pan Blockade of 2-arachidonylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) enhances retrograde endocannabinoid signaling. J.Pharm.Exp.Ther. 2009 PMID: 19666749
Kinsey Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. J.Pharmacol.Exp.Ther. 2013 PMID: 23412396
Long Selective blockade of 2-arachidonylglycerol hydrolysis produces cannabinoid behavioral effects. Nat.Chem.Biol. 2009 PMID: 19029917