JWH 133

Tocris Bioscience, part of Bio-Techne | Catalog # 1343

(1)

Citations (179)

COA / SDS

Potent and selective CB2 agonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective CB2 agonist

View all Cannabinoid R2/CB2 Agonists »

Product Description

JWH 133 is a potent CB₂ selective agonist (K_i = 3.4 nM). Approx. 200-fold selective over CB₁ receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40.

Product Specifications

Molecular Weight

312.49

Formula

C₂₂H₃₂O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran

CAS Number

259869-55-1

PubChem ID

6918505

InChI Key

YSBFLLZNALVODA-RBUKOAKNSA-N

SMILES

[H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	6.25	20
	Ethanol	31.25	100

Preparing Stock Solutions for JWH 133

The following data is based on the product molecular weight 312.49

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.00 mL	32.00 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Pertwee Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 1999 PMID: 10469884
Correa Activation of cannabinoid CB₂ receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br.J.Pharmacol. 2005 PMID: 15821753
Huffman 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB₂ receptor. Bioorg.Med.Chem. 1999 PMID: 10658595
Baker Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 2000 PMID: 10716447