JW 67

Name: JW 67
Brand: Tocris Bioscience
SKU: 4651
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4651

(1)

COA / SDS

Wnt pathway inhibitor; induces degradation of active β-catenin

Discontinued Product

4651 has been discontinued. View all Other Wnt Signaling Inhibitors products.

Key Product Details

Description:	Wnt pathway inhibitor; induces degradation of active β-catenin
Chemical Name:	Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
Purity:	≥97% (HPLC)
Molecular Weight:	394.38

View Full Technical Details for JW 67

Technical Data
Citations / Reviews (1)

Biological Activity for JW 67

JW 67 is an inhibitor of canonical Wnt pathway signaling (IC₅₀ = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G₁/S cell cycle progression in colorectal cancer (CRC) cell lines (GI₅₀ = 7.8 μM).

Compound Libraries for JW 67

JW 67 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for JW 67

M. Wt	394.38
Formula	C₂₁H₁₈N₂O₆
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	442644-28-2
PubChem ID	644733
InChi Key	BTXRSHKJNDFHGA-UHFFFAOYSA-N
Smiles	O=C1NC6=C(C=CC=C6)C21OCC3(COC(C(NC5=C4C=CC=C5)=O)4OC3)CO2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JW 67

References are publications that support the biological activity of the product.

Waaler Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011 PMID: 21199802
Shultz [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 2012 PMID: 22260203