JW 55
Tocris Bioscience, part of Bio-Techne | Catalog # 4514
Tankyrase inhibitor
Discontinued Product
4514 has been discontinued.
View all Tankyrase Inhibitors products.
Product Description
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of JW55 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
434.48
Formula
C25H26N2O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
CAS Number
664993-53-7
PubChem ID
2946601
InChI Key
ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
SMILES
O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.45 | 100 | |
| Ethanol | 43.45 | 100 |
Preparing Stock Solutions
for JW 55
The following data is based on the product molecular weight 434.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.60 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Waaler A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 PMID: 22440753
Product Specific Notices for JW 55
For research use only
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