JW 480
Tocris Bioscience, part of Bio-Techne | Catalog # 4327
Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Key Product Details
Description
Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Product Description
JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.Licensing Information
Sold under license from The Scripps Research Institute.Product Specifications
Molecular Weight
333.42
Formula
C22H23NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
CAS Number
1354359-53-7
PubChem ID
57330099
InChI Key
PCNJGBMWAZRVEA-UHFFFAOYSA-N
SMILES
CC(C)C1=CC=CC=C1OC(NCCC2=CC=C(C=CC=C3)C3=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.34 | 100 | |
| Ethanol | 33.34 | 100 |
Preparing Stock Solutions
for JW 480
The following data is based on the product molecular weight 333.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.00 mL | 15.00 mL | 29.99 mL |
| 5 mM | 0.60 mL | 3.00 mL | 6.00 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.00 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chang A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 2011 PMID: 21513884
Product Specific Notices for JW 480
For research use only
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