JTP 103237

Name: JTP 103237
Brand: Tocris Bioscience
SKU: 6765

Tocris Bioscience, part of Bio-Techne | Catalog # 6765

COA / SDS

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor

Discontinued Product

6765 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description:	Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor
Chemical Name:	7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine
Purity:	≥98% (HPLC)
Molecular Weight:	474.52

View Full Technical Details for JTP 103237

Technical Data
Citations

Biological Activity for JTP 103237

JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC₅₀ = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.

Compound Libraries for JTP 103237

JTP 103237 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JTP 103237

M. Wt	474.52
Formula	C₂₄H₂₉F₃N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1883864-16-1
PubChem ID	91884614
InChi Key	KELNXHBJTXCXSN-UHFFFAOYSA-N
Smiles	CC(C)(C1=CC(C(C)(C)C)=NC(N2CCN3C(C2)=NN=C3C4=CC=C(C=C4)OC(F)(F)F)=N1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JTP 103237

References are publications that support the biological activity of the product.

Okuma JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J.Pharmacol.Sci. 2015 PMID: 26215699
Okuma JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur.J.Pharmacol. 2015 PMID: 25857225