JTC 801

Name: JTC 801
Brand: Tocris Bioscience
SKU: 2481

Tocris Bioscience, part of Bio-Techne | Catalog # 2481

Citations (14)

COA / SDS

Selective NOP antagonist

Key Product Details

Description:	Selective NOP antagonist
Chemical Name:	N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	447.96

View Full Technical Details for JTC 801

Technical Data
Citations

Biological Activity for JTC 801

JTC 801 is a high affinity, selective NOP receptor antagonist (K_i = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo. Orally active.

Compound Libraries for JTC 801

JTC 801 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JTC 801

M. Wt	447.96
Formula	C₂₆H₂₅N₃O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	244218-51-7
PubChem ID	5311339
InChi Key	NQLIYKXNAXKMBL-UHFFFAOYSA-N
Smiles	Cl.CCC1=CC=C(OCC2=CC=CC=C2C(=O)NC2=CC3=C(N)C=C(C)N=C3C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JTC 801

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.8	100
	ethanol	8.96	20

Preparing Stock Solutions for JTC 801

The following data is based on the product molecular weight 447.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.16 mL	22.32 mL
5 mM	0.45 mL	2.23 mL	4.46 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for JTC 801

References are publications that support the biological activity of the product.

Yamada Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801. Br.J.Pharmacol. 2002 PMID: 11815367
Tamai Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. Eur.J.Pharmacol. 2005 PMID: 15763246
Shinkai 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J.Med.Chem 2000 PMID: 11101358